Postdoc Carla Rosenfeld accepts new position at Northwestern

This is one of the most bittersweet posts I have ever written.  Postdoc Carla Rosenfeld recently left the Santelli lab for her newest amazing academic adventures.  Carla is now the associate director of the Quantitative Bioelement Imaging Center at Northwestern University.  Huge congrats to Carla for this incredible opportunity!!  We will miss her (and her delicious baked goods) so very much but are super proud of her.  Northwestern is very lucky to have her.  Fortunately, Carla will still be able to continue with some of the ongoing research projects in the lab!

Riley Schmitter receives a UROP award

A huge congrats to Riley Schmitter, who received a competitive Grand Challenges Undergraduate Research Opportunities Program (GC UROP) award!!!  Riley is an undergrad working on the project: Wild Rice in Minnesota and the Great Lakes Region: A Flagship for Environmental Preservation and Indigenous Resource Sovereignty.

This award will support Riley as she investigates the impact of iron and phosphate on wild rice ecosystems.


Mary Sabuda awarded a grad fellowship

Congratulations to Mary Sabuda for being awarded a one-year UMII MnDRIVE Graduate Assistantship!! Mary’s successful proposal is on: Elucidating fungal bio-transformations of selenium using geochemical and genomic approaches: implications for the bioremediation of contaminated environments.

These fellowships are awarded to PhD graduate students currently pursuing research at the University of Minnesota at the intersection of informatics and any of the four MnDRIVE focus areas.  More info on these awards can be found here:

Cara receives an NSF CAREER Award


Cara received a Faculty Early Career Development Program (CAREER) Award from the National Science Foundation to conduct research to understand how fungi transform selenium, making it more or less bioavailable or toxic in the natural environment. This work was co-funded by the Geobiology and Low-Temperature Geochemistry program, the Systems and Synthetic Biology program, and the Education and Human Resources Program.

“CAREER: Genome-enabled investigations into the mechanisms and ecological controls on selenium transformations by fungi”

Here is the abstract of the project:

Selenium (Se), sometimes referred to as “the essential toxin”, plays an important role in human and ecosystem health. Selenium is a required micronutrient for most living organisms. At elevated concentrations, however, Se is a toxic element of increasing environmental concern. Selenium bioavailability and toxicity largely depends on the form, or oxidation state, of the compound. Microorganisms, including fungi, play an important role in controlling and transforming Se chemical speciation by promoting a variety of chemical reactions. The processes by which fungi promote Se transformations, however, are largely unresolved, thus limiting knowledge of their specific contributions in nature. Using a genome-enabled approach, this research will examine and resolve the relevant fungal biogeochemical processes that transform Se speciation and ultimately influence the fate and distribution of selenium in nature. Results from the proposed research will also directly inform new technologies for Se bioremediation and will be of additional interest to government and local stake-holders who are regulating or managing Se issues. Through formal student training and engagement in public science communication in collaboration with local museums, this project will further engage, inform, and inspire students and the public on the important role that microorganisms play in maintaining and improving the overall health of planet Earth.

To better understand the impact of fungi on biogeochemical processes that influence the fate of selenium in nature, this research will illuminate the currently unresolved molecular mechanisms and pathways that contribute to the aerobic reductive transformation of soluble, toxic Se oxyanions (selenate and selenite) to insoluble Se(0) and organic, volatile Se(-II) compounds by a diverse suite of environmentally-relevant Ascomycete fungi. The specific research objectives are to (1) identify the fungal mechanisms of selenate and selenite reduction in oxic environments, (2) assess the effects of key nutrients and trace metals on fungal Se transformation mechanisms and reaction products, and (3) investigate particle size, morphology, and structure of Se biomineralization products with respect to fungal growth conditions and Se reduction pathway. The genome-enabled approach will elucidate the genes and proteins that contribute to Se reduction by linking their expression to specific functions and resulting Se biominerals and organoselenium compounds. This approach will lead to the development of gene regulatory networks for these common fungal species, which will be highly beneficial for predicting the effect of environmental or biological change on Se speciation and will further benefit the advancement of fungal research in environmental and biological sciences. This project is jointly funded by the Geobiology and Low-Temperature Geochemistry Program in the Division of Earth Sciences and the Systems and Synthetic Biology Cluster in the Division of Molecular and Cellular Biosciences.



New paper out!

A new study led by Dr. Carla Rosenfeld examines the impact of mining and selenium pollution on microbial communities.  The study, Persistent Bacterial and Fungal Community Shifts Exhibited in Selenium-Contaminated Reclaimed Mine Soils was published in Applied and Environmental Microbiology.  The paper is freely available here through open access at AEM.

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